introduction

Edibles, or cannabis products that can be eaten, have a completely different effect than smoking or vaping. While inhaling allows THC to enter the bloodstream directly through the lungs, edibles must first pass through the digestive tract. This results in a slower, but often significantly more intense, effect. Many people underestimate this – and are surprised when the high hits with full force.

Absorption pathways in the body

The route via the gastrointestinal tract

After consuming an edible, the THC, along with fats or sugars, enters the small intestine. There it is absorbed through the intestinal lining and transported to the liver – and that's precisely where the crucial process happens.

First-pass metabolism in the liver

In the liver, THC is converted to 11-hydroxy-THC – a more active compound that is two to three times stronger and more easily reaches the brain. This explains the deeper, longer-lasting effects of edibles compared to smoking.

Onset of action, duration of action & reduction

While the effects of smoking are noticeable within minutes, with edibles it takes an average of 30–120 minutes . The full effect builds up over 2–4 hours and can last up to 12 hours in total.

• Stomach contents: It works faster on an empty stomach.
• Body weight & metabolism: Faster metabolism = faster absorption.
• THC dose & fat content: Fat facilitates the absorption of fat-soluble cannabinoids.

Tip: Patience is crucial – taking more quickly leads to an overdose.

Influence of cannabinoids & terpenes

Cannabinoids

• THC (Δ9-Tetrahydrocannabinol): Mainly responsible for the psychoactive effect.
• CBD (Cannabidiol): Non-intoxicating, anxiolytic, relaxing.
• CBN, CBG, CBC: Subtly support the overall effect.

Terpenes

• Myrcene: Causes drowsiness, promotes THC absorption.
• Lemons: Invigorating and mood-lifting.
• Linalool: Relaxing, anxiety-relieving.
• Caryophyllene: Anti-inflammatory, physically grounding.

This interplay is called the entourage effect – the synergy of all the active ingredients that makes cannabis so unique.

Edibles vs. Smoking vs. Vaping

Practical tips for safe consumption

1. Start slowly: Begin with 2–5 mg of THC, especially for beginners.
2. Wait at least 2 hours: Only administer additional doses after this time.
3. Don't forget fat: A snack containing fat (e.g. nuts) improves absorption.
4. CBD as a buffer: Can mitigate the effects of THC.
5. Hydration & Rest: If the effect is too strong: Water, rest, CBD or peppermint tea can help.

Conclusion

Edibles have a strong, long-lasting, and profound effect – but only if you understand how the body processes them. The conversion to 11-hydroxy-THC in the liver is key. Those who know this can enjoy cannabis edibles intentionally – without unpleasant surprises.

Frequently Asked Questions (FAQ)